||15:00 - 16:15
|Stem cells how close are we to application in ophthalmology? Symposium der Sektion DOG-Genetik
The use of stem cells for disease modeling and cell therapeutic applications is currently at the height of debate in Experimental Ophthalmology. In this symposium, the speaker will highlight the current state of the art in generating and maintaining stem cells, in generating 3D organoid culture systems, as well as in developing treatment approaches for inherited retinal dystrophies.
|Transplantation of photoreceptors generated from ipSCs - future prospects and limitations||Do19-01 |
|Stem cell therapy for retinal diseases: Focus on RPE cell transplantation||Do19-02 |
Tim U. Krohne
Ophthalmology is at the forefront of the development of clinical applications for stem cells, and retinal diseases such as age-related macular degeneration and Stargardts disease represent the targets of the first clinical trials employing pluripotent stem cells in humans. An update on the results of the first concluded clinical trials as well as on design and concept of upcoming trials is given.
|The use of murine and human 3D organoids of the retina to describe phenotypic changes||Do19-03 |
|Stem cell differentiation and 3D organoid generation with regard to potential therapeutic application||Do19-04 |
3-dimensional retinal organoids derived from human induced pluripotent stem cells represent a unique human in vitro platform to study human retinal diseases. Moreover, this system my be used for pharmacological studies, e.g. for drug testing and toxicity sreening.